Steroids Powder Estradiol Benzoate

Steroids Powder Estradiol Benzoate

Steroids Powder Estradiol Benzoate Quick Details Description Estradiol Benzoate is a sex hormone that is present in both males and females, and is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well...

Product Details

Steroids Powder Estradiol Benzoate


Quick Details


Product name

Estradiol benzoate

Other name

17-beta-oestradiol3-benzoate ; β-Estradiol 3-benzoate

CAS register number

50-50-0

EINECS

200-043-7

Molecular formula

C25H28O3

Molecular weight

376.49

Molecular structure

Melting point

192~198°C

Assay

98%



Description 


Estradiol Benzoate is a sex hormone that is present in both males and females, and is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well as in the growth of certain bones. It also governs the distribution of body fat in women and is the main hormone responsible for the fact that women are shorter than men, on average. Both the ovaries and the adrenal glands produce it.

As a sex hormone, it also triggers many of the developments of the reproductive system that begin in puberty. It is present throughout the reproductive years, and declines during and after menopause. This decline is precisely what causes many of the symptoms of menopause, such as hot flashes and night sweats, vaginal dryness, and the loss of bone mass that may lead to osteoporosis.


Specification:


ITEM

SPECIFICATION
Assay≥99%
DescriptionWhite powder
Specific rotation+55°~+59°
Loss on drying≤1%
Total heavy metals≤10ppm

product Name

estradiol benzoate
Synonymsbeta-Estradiol-3-benzoate; Oestradiol Benzoate; 17beta-Estradiol benzoate
Molecular FormulaC25H28O3
Molecular Weight376.488
InChIInChI=1/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1
CAS Registry Number50-50-0
EINECS200-043-7
Density1.185g/cm3
Melting point191-198°C
Boiling point531.2°C at 760 mmHg
Refractive index1.604
Flash point212°C
Vapour Pressur4.08E-12mmHg at 25°C



Usage


Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an
estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the
treatment of lesions produced by diminution of bodily production of estrogens.

Estradiol benzoate (INN; brand names Agofollin, Diffolisterol, Progynon-B, many others), or oestradiol benzoate (BAN), is a synthetic ester, specifically the 3-benzoyl ester, of the natural estrogen, estradiol. It was the first form of estrogen to be marketed, patented by Schering-Kahlbaum in 1936 in an oil preparation for injectable use and introduced later that year as Progynon-B. Though it is still in widespread use today, it has been mostly superseded by newer forms of estradiol with improved pharmacokinetics that require less frequent administration such as estradiol cypionate and estradiol valerate.



Application


Women's menstrual cycle involves several predictable changes in hormone levels, of which Estradiol Benzoateis one of them. Participate in the ovulation process, prepare the endometrial implant, the egg should be fertilized. Some tests on baboons and other primates show that his hormones also play a sustained role in maintaining pregnancy and contribute to the duration of pregnancy.


As a sex hormone, Estradiol Benzoatealso triggers many of the development of adolescent reproductive systems. It exists throughout the reproductive year and falls during and after menopause. This decline is the result of many symptoms of menopausal symptoms, such as hot flashes and night sweats, vaginal dryness and bone loss that may lead to osteoporosis.


COA

Product name

Estradiol Benzoate

Appearance

White crystalline powder

Water

≤3.5%

pass

Assay

97 .0~ 103.0%

99.2%

Loss on drying

≤0.5%

0.17%

Related substances

total impurities ≤1.0%

Pass

any individual impurity ≤0.5%

Pass

Residual solvents

ethanol ≤0.5%

Pass


Dosge

A single dose of 2.5 mg estradiol benzoate by intramuscular injection was found to produce plasma estradiol levels of >400 pg/mL, measured 24 hours post-injection, in a group of patients with minimal baseline levels of estradiol (due to GnRH analogue therapy with triptorelin).

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