Pharmaceutical Raw Materials Quetiapine Fumarate
English name: QUETIAPINE HEMIFUMARATE
CAS No .: 111974-72-2
Molecular formula: C46H54N6O8S2
Molecular weight: 883.09
Standard: Enterprise standard
Natural / synthetic: synthetic
Level: Medical grade
Appearance: white powder
Category: Pharmaceutical raw materials
Area: Non-antipsychotic drugs
Quetiapine fumarate is an antipsychotics, developed by the United States AstraZeneca, a variety of neurotransmitter receptors interact in the brain, the serotonin (5-HT2) receptor Has a high affinity and is greater than the affinity for dopamine D1 and dopamine D2 receptors in the brain. Quetiapine also has high affinity for the histamine H1 receptor and the adrenergic alpha 1 receptor with low affinity for the adrenergic alpha 2 receptor but not for the cholinergic muscarinic receptor or the benzodiazepine receptor No affinity. Counteracting psychotic activity measurements such as conditioned avoidance reflex positive results. Clinically, it is mainly used for the treatment of major depressive disorder in adults, acute manic episode of bipolar disorder and various types of schizophrenia. Not only positive symptoms of schizophrenia effective, negative symptoms have some effect. It also alleviates the emotional symptoms associated with schizophrenia such as depression, anxiety and cognitive deficits. Mainly used to treat schizophrenia.
|Product name||Quetiapine fumarate|
|Production date||shelf life||2 years|
|Items of analysis||Specification||results|
|Description||White crystalline powder;odorless(Visual)||pass|
|solubility||freely soluble in glacial acetic acid,slightly soluble in water and ethanol.||pass|
|identification||1.positive reaction of potassium permanganate.|
2.consistent with the IR spectrum of the standard
|Any unknown impurity||≤0.10%||0.07%|
|assay||Quetiapine Fumarate 99.0%~101.0%(anhydrous substance)||100.1%|
|total bacterial count||≤1000cfu/g (in-house)||<10cfu/g|
|total yeasts & moulds count||≤100cfu/g (in-house)||<10cfu/g|
|escherichia coli||absent (in-house)||ND|
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