Sildenafil Citrate Viagra Anabolic Steroid

Sildenafil Citrate Viagra Anabolic Steroid

Sildenafil Citrate Viagra Anabolic Steroid Quick Details Description Sildenafil citrate is the raw material of Viagra, viagra treats erectile dys function and works by relaxing muscles and increases blood flow to particular areas of the body (in this case, the penis, specifically). Its effects...

Product Details

Sildenafil Citrate Viagra Anabolic Steroid



Quick Details 


Product Name

sildenafil citrate

CAS No

171599-83-0

Synonyms

Sildenafil citrate; viagra

Assay

98%

MF

C28H38N6O11S

MW

666.7

Appearance

Solid

Brand

NJBN STEROID

Delivery time

within 24 hours upon receipt of payment

Shippment

EMS, DHL, TNT, FedEx, UPS

Usage

An orally active selective type 5 cGMP phosphodiesterase inhibitor Biological Activity :Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC 50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.

Melting point

187-189°C



Description


Sildenafil citrate is the raw material of Viagra, viagra treats erectile dys function and works by relaxing muscles and increases blood flow to particular areas of the body (in this case, the penis, specifically). Its effects last up to four hours. The most common side effects of Viagra are headache, facial flushing, and upset stomach. Rarely, blurred vision, or sensitivity to light may briefly occur.


As well as treating impotence, Sildenafil Citrate can also be effective in treating Pulmonary Arterial Hypertension (PAH). Similarly to how it acts to relax muscles of the penis, it relaxes arterial walls; therefore, reducing resistance and pressure in the arteries.


Sildenafil Citrate is solely active in relaxing muscles and increasing blood flow to the heart, lungs and penis due to PDE-5, yet vasodilation is not increased in other parts of the body.


Technical Data: In studies where Viagra was administered to over 3700 patients, 19-87 years old in world wide clinical trials. More than 550 patients received treatment post 1 year. 2.5% of the Viagra subjects and 2.3% of the placebo subjects reported adverse effects, which were all considered mild. These reported side effects included abnormal or blurred vision and increased sensitivity to light.


All other negative reactions reported, including URI, flu symptoms, back pain and arthralgia, occurred at a rate of less than 2% and equally common in the placebo and Viagra administered groups. Effects worsened and were reported more frequently as dosages increased.


Other studies measured duration of sexually stimulated erection using a Rigiscan device. Duration of rigidity was increased by 60% with Viagra use.



Application


Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was originally discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett.

The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction in all settings, including diabetes.

In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, dyspepsia, nasal congestion and impaired vision, including photophobia and blurred vision.Some sildenafil users have complained of seeing everything tinted blue (cyanopsia).Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA found that sildenafil could lead to vision impairment in rare cases and a number of studies have linked sildenafil use with nonarteritic anterior ischemic optic neuropathy.

Rare but serious adverse effects found through postmarketing surveillance include priapism, severe hypotension, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. As a result of these postmarketing reports, in October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss.




Specification:


Product name

Sildenafil Citrate

Appearance

White crystalline powder

Loss on drying

≤1.0%

0.3%

Acidity

3.0-5.0

4.1

Residue on ignition

≤0.1%

0.05%

Heavy metals

≤20ppm

Complies

Relevant impurity

≤0.5%

0.02%

Methanol

≤0.3%

0.025%

Methylene dichloride

≤0.06%

0.013%

N,N-Dimethyl formamide

≤0.088%

Not detected

Assay(on dried basis)

≥98%

98.4%



Sildenafil Dosage


Viagra:for erectile dysfunction, comes in blue, diamond-shaped pills, in doses of 25, 50, or 100 milligrams. The patient takes a maximum of one pill in a 24-hour period, between 30 minutes to 1 hour before sexual intercourse.


Revatio:for pulmonary arterial hypertension, comes in white, round, film-coated tablets. Patients take one 20 mg Revatio tablet three times a day.


The main function :


Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in

men.


Sildenafil (Revatio) is used to improve the ability to exercise in people with pulmonary arterial

hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of

breath, dizziness, and tiredness).


Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation.


This increased blood flow can cause an erection. Sildenafil treats PAH by relaxing the blood

vessels in the lungs to allow blood to flow easily.


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