Local Anesthetic Powder Dibucaine Hydrochloride

Local Anesthetic Powder Dibucaine Hydrochloride

Local Anesthetic Powder Dibucaine Hydrochloride Quick details Description Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted....

Product Details

Local Anesthetic Powder Dibucaine Hydrochloride 



Quick details 


Product name


Dibucaine hydrochloride


CAS


61-12-1


Molecular Formula


C20H30ClN3O2


Molecular Weight


379.92


EINECS


200-498-1


Density


1.071g/cm3


Melting Point


99-101 °C(lit.)


Boiling Point


496.3 °C at 760 mmHg


Flash Point


254 °C


Appearance


White powder




Description


Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws.



Applications


Spinal anesthesia (high, low, saddle block) and topically to produce surface anesthesia. Eye: To anesthetize conjunctiva and cornea prior to superficial procedures (including tonometry, gonioscopy, removal of foreign bodies or sutures, corneal scraping).
Nose and Throat: To abolish laryngeal and esophageal reflexes prior to bronchoscopy, esophagoscopy.
Skin: To relieve pruritus, pain, burning.



COA:


Item

Standard


Result

CharacteristicsA white or almost white crystalline powder
Conform
IdentificationShould meet related requirements
Conform
Appearance of solutionShould meet related requirements
Passed
PH3.5-5.5
4.5
Specific optical rotation+135°~+150°
+143°
Boiling point350.8°C at 760 mmHg
Conform
Flash point166°C
Conform
Lincomycin B5.0% max
2.9%
Heavy metals5ppm max
Conform
Residue on ignition0.5% max
0.1%
Water3.1-4.6%
4.3%
Bacterial endotoxinssmaller than 0.5IU/mg
smaller than 0.5IU/mg
Assay
Not less than 89.5% and not more than 102.0% of lincomycin (C18H35ClN2O6S))
99.5%



Dibucaine Hydrochloride Usage


Dibucaine hydrochloride is often a local anesthetic from the amide type now generally employed for surface anesthesia. It really is one of the most potent and toxic with the long-acting local anesthetics and its particular parenteral use is restricted. The drug blocks the two initiation and conduction of nerve impulses by lowering the neuronal membrane's permeability to sodium ions. It can be one of the most potent and toxic with the long-acting local anesthetics as well as parenteral use is restricted to spinal anesthesia.


Indication: For creation of local or regional anesthesia by infiltration techniques including percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques for example brachial plexus and intercostal and by central neural techniques for example lumbar and caudal epidural blocks. Dibucaine Hydrochloride is an amide-type local anesthetic, comparable to lidocaine.


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