Local Anesthetic Powder Dibucaine Hydrochloride
Quick details
Product name | Dibucaine hydrochloride |
CAS | 61-12-1 |
Molecular Formula | C20H30ClN3O2 |
Molecular Weight | 379.92 |
EINECS | 200-498-1 |
Density | 1.071g/cm3 |
Melting Point | 99-101 °C(lit.) |
Boiling Point | 496.3 °C at 760 mmHg |
Flash Point | 254 °C |
Appearance | White powder |
Description
Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws.
Applications
Spinal anesthesia (high, low, saddle block) and topically to produce surface anesthesia. Eye: To anesthetize conjunctiva and cornea prior to superficial procedures (including tonometry, gonioscopy, removal of foreign bodies or sutures, corneal scraping).
Nose and Throat: To abolish laryngeal and esophageal reflexes prior to bronchoscopy, esophagoscopy.
Skin: To relieve pruritus, pain, burning.
COA:
Item | Standard | Result |
| Characteristics | A white or almost white crystalline powder | Conform |
| Identification | Should meet related requirements | Conform |
| Appearance of solution | Should meet related requirements | Passed |
| PH | 3.5-5.5 | 4.5 |
| Specific optical rotation | +135°~+150° | +143° |
| Boiling point | 350.8°C at 760 mmHg | Conform |
| Flash point | 166°C | Conform |
| Lincomycin B | 5.0% max | 2.9% |
| Heavy metals | 5ppm max | Conform |
| Residue on ignition | 0.5% max | 0.1% |
| Water | 3.1-4.6% | 4.3% |
| Bacterial endotoxins | smaller than 0.5IU/mg | smaller than 0.5IU/mg |
| Assay | Not less than 89.5% and not more than 102.0% of lincomycin (C18H35ClN2O6S)) | 99.5% |
Dibucaine Hydrochloride Usage
Dibucaine hydrochloride is often a local anesthetic from the amide type now generally employed for surface anesthesia. It really is one of the most potent and toxic with the long-acting local anesthetics and its particular parenteral use is restricted. The drug blocks the two initiation and conduction of nerve impulses by lowering the neuronal membrane's permeability to sodium ions. It can be one of the most potent and toxic with the long-acting local anesthetics as well as parenteral use is restricted to spinal anesthesia.
Indication: For creation of local or regional anesthesia by infiltration techniques including percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques for example brachial plexus and intercostal and by central neural techniques for example lumbar and caudal epidural blocks. Dibucaine Hydrochloride is an amide-type local anesthetic, comparable to lidocaine.
