Quick Detail:
CAS | 189691-06-3 |
SYNONYMS | PT-141, Bremelanotide |
SEQUENCE | Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys-OH) |
CHEMICAL NAME | NA |
MOLECULAR FORMULA | C50H68N14O10 |
MOLECULAR WEIGHT | 1025.16 |
PURITY | ≥98% (HPLC) |
PHYSICAL STATE | Lyophilized Powder |
SOLUBILITY | Soluble in water or 1% acetic acid |
STORAGE | Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C.Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C. |
Applications:
PT-141 functions by activating the melanocortin 1 receptor and MC4R namely. Bremelanotide originally was tested for nasal spray delivery but was discontinued after concerns about side effects. Bremelanotide PT141, as Melanotan II, may cause spontaneous arousal enhancing effect. Unlike other supplements, pt 141 results do not act on the vascular body, but directly increases desires through the nervous system.
PT-141 or Bremelanotide is the generic term for a peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). PT-141 has a similar structure to Melanotan-II and is a synthetic analogue of alpha-Melanocyte stimulating hormone (α-MSH). Alpha-MSH is an endogenous peptide that has potential influence over lipid metabolism, appetite, and sexual libido. PT-141 is a potential remedy for the treatment of sexual dysfunction and studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.
Description and Usage:
Bremelanotide or PT-141 is the generic term for a new research peptide for use in helping improve sexual dysfunction in men (erectile dysfunction or impotence) as well as helping improve sexual dysfunction in women (sexual arouseal disorder).
Bremelanotide, PT-141 does not act on the vascular system like the former compounds but it is known and has been shown to help increase sexual activity in both male and female mammals. Bremelanotide PT-141 allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.
PT-141, bremelanotide is experimental and is used for the purpose of sexual aroGloball. It is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.
PT141 Dosage:
Dosages -
for men:
.5 mg = light
1.0mg = moderate
2.0mg = heavy
women are about half the dose of men.
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