Ceritinib For lung Cancer

Ceritinib For lung Cancer

Ceritinib for lung cancer Specifications Description Ceritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase...

Product Details

Ceritinib for lung cancer


Specifications

Product nameCeritinib (LDK378)
AliasCeritinib
CAS1032900-25-6
MFC28H36ClN5O3S
MW558.14
Purity>99%
Assay99%min
AppearanceWhite powder
Mini Order10 grams
StorageDry and airproof place
Package1kg/Aluminium Foil Bag or as Required
Shelf life2 years
StorageCeritinib should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
PaymentT/T, Western Union, MoneyGram, Bank Transfer ,Paypal
Lead time3-7 days
Delivery Time7-14 Days Door to Door
Shipping OptionChina EMS,DHL,ect


Description

Ceritinib, also known as LDK378, is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib.Ceritinib is a drug for the treatment of lung cancer. Ceritinib is an ALK inhibitor.Ceritinib was approved in April 2014 by the Food and Drug Administration for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) following treatment with crizotinib.

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Application

Ceritinib (LDK378) is designed to reduce the possibility of forming reactive metabolites and shows undetectable levels of glutathione (GSH) adducts (<1%) in liver microsomes. LDK378 has relatively good metabolic stability, with moderate CYP3A4 (Midazolam substrate) inhibition and hERG inhibition. LDK378 exhibits low plasma clearance in animals (mouse, rat, dog and monkey) compared to liver blood flow, with the oral bioavailability of above 55% in mouse, rat, dog and monkey. LDK378 induces a dose-dependent growth inhibition and tumor regression in the Karpas299 and H2228 rat xenograft models, with no body-weight loss.


FAQ

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What about the payment,Is it secure?

A:Payment can be TT, West Union, Money Gram and Bitcoin. As a well-known supplier, thousands of buyers pay asmentioned. It is warmly welcome to visit our company, discuss and deal face to face.

 

Have your product quality been approved by Third Party Lab?

A:Yes,All products are strictly tested by our QC,confirmed by QA and approved by third party lab in China,USA,Canada,Germany,UK,Italy,France etc.So you will be assured with Good Quality if you choose us.

 

Do you accept sample order?

A:Yes,we accept small order from 10g,100g and 1kg for your evaluation quality of our goods.

 

Is there any discount?

A:Yes,for larger quantity,we always support with better price.

 

Do you have any reshipment policy?

A:Yes we will reship for totally free if your parcles is seizd by customs unlucky,you dont need to pay any more money

 

Our advantages:
1) Best prices with satisfied quality.
2) Rich experienced in delivering the parcels to you.
3) Enough stock ensure the prompt delivery time.
4) Good after-sales service.
5) Package will be reshipped if sent failed.
6) Specials are possible when the order is big enough.
7)For most products we can provide you a sample, while the cost should undertake by your side.



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